| Multiple Endocrine Neoplasia (MEN) Syndrome | |
|---|---|
| MEN - I |
|
| MEN - II (Sipple's Syndrome) |
|
| MEN - III |
|
Multiple Endocrine Neoplasia or MEN Syndrome are classified into following types :
A. MEN - I
- Hyperplasia of pituitary gland with acromegaly
- Hyperplasia of parathyroid and adrenal cortex
- Hyperplasia of pancreatic islets with increased production of gastrin, insulin, and glucagon with peptic ulcers and gastric hypersecretion
B. MEN - II
- Hyperplasia of parathyroid gland
- No tumors of pancreas. No peptic ulcer.
- Patients may have pheochromocytomas of the adrenal medulla and medullary carcinoma of the thyroid gland
C. MEN - III
- Pheochromocytomas and Medullary carcinoma of the thyroid gland
- Oral neuromas that are common on lips, tongue and buccal mucosa.
- The lips are described as Bumpy lips.