MCQs on Hematology and Endocrinology Part 2 - General Medicine MCQs

The correct answers are highlighted in green.

# Enzyme deficient in diabetes mellitus is: (TNPSC-99)
a) Glucokinase
b) Hexokinase
c) Phosphorylase

d) Pyrophosphate dehydrogenase

# Which of the following neoplasms is primary in the adrenal medulla? (APPSC-99)

a) Pheochromocytoma

b) Eosinophilic adenoma

c) Arrhenoblastoma

d) None of the above

# Glycosylated haemoglobin assay is helpful in the monitoring of patients with: (KCET-07)

a) Addison's disease

b) Diabetes Mellitus

c) Cushing's disease

d) Graves' disease

# Most specific histological lesion in diabetic nephropathy is: (KCET-07)

a) Widening of glomerular basement membrane

b) Generalized mesangial thickening

c) Occlusion of glomeruli with fibrin caps

d) Hyalinization of afferent arterioles and Kimmelsteil- Wilson bodies

# Long term assessment of glucose control can be made by: (COMEDK-07, AIIMS-07)

a) Estimation of post prandial blood sugar

b) Estimation of fasting blood sugar

c) Estimation of urine sugar level

d) Estimation of blood level of glycosylated hemoglobin

#  The DCCT (Diabetes Control & Complication Trial) provided definitive proof that reduction in chronic hyperglycemia helps to improve: (COMEDK-07)

a) Micro vascular complications of Type I DM

b) Macro vascular complications of Type I DM

c) Micro vascular complications of Type II DM

d) Macro vascular complications of Type II DM

# Rotten apple smell of breath is associated with: (KCET-07)

a) Liver insufficiency

b) Kidney insufficiency

c) Unbalanced insulin dependent diabetes

d) Respiratory problems

# Bisphosphonates act by: (AIPG-06)

a) Increasing the osteoid formation

b) Increasing the mineralization of osteoid

c) Decreasing the osteoclast mediated resorption of bone

d) Decreasing the parathyroid hormone secretion

# Haemorrhage secondary to heparin administration can be corrected by administration of: (AIIMS-06)

a) Vitamin K

b) Whole blood

c) Protamine

d) Ascorbic add

# Gall bladder enlargement occurs in: (KAR-04)

a) Carcinoma of pancreas

b) Hepatic cirrhosis

c) Chronic hepatitis

d) Chronic cholelithiasis

# What are the symptoms of diabetes mellitus? (KAR-04)

a) Polydipsia

b) Polyuria

c) Polyphagia

d) All of the above

# Reticulocytosis is not a feature of:

a) Paroxysmal nocturnal haemoglobinemia

b) Following acute bleeding

c) Hereditary spherocytosis

d) Anaemia in CRF

# Acid phosphatase is associated with: (AIPG-07)

a) T-lymphocyte

b) B-lymphocyte

c) Myelocyte

d) Monocytes

# For the microbiological assay of Vit. B12, the following bacteria is used: (COMEDK-07)

a) Corynebacterium diptheriae

b) Streptococcus pyogenes

c) Esch coli

d) Lactobacillus leishmannii

# Increased LAP score is seen in: (AIPG-07)

a) Chronic myeloid leukemia

b) Myelofibrosis

c) PNH

d) Megaloblastic anemia

# Osmotic fragility is increased in: (COMEDK-07)

a) Sickle cell anemia

b) Hereditary spherocytosis

c) Thalassaemia

d) Chronic lead poisoning

# Hemoglobin which has diagnostic value in diabetes mellitus: (BHU-07)

a) HbA

b) HbF

c) HbA1

d) HbS

# Administration of folic acid in pernicious anaemia will largely: (COMEDK-10)

a) Correct the anaemia but not the neurological symptoms

b) Correct the anaemia and the neurological symptoms

c) Correct the neurological symptoms but not the anaemia

d) Correct neither neurological symptoms nor anaemia

# Glycosylated hemoglobin assay (HbA1c) level of 4% - 6% indicates: (IGNOU-10)

a) Normal value

b) Good diabetes control

c) Moderate diabetes control

d) Poor diabetes control

# Spontaneous mouth petechiae and gingival bleeding occur typically at platelet levels: (COMEDK-10)

a) Between 300,000 - 500,000/mm3

b) Between 20,000-30,000/mm3

c) Between 150,000-170,000/mm3

d) Between 70,000-185,000/mm3

# All are true for Philadelphia chromosome, EXCEPT: (MCET-07)

a) Acquired genetic defect

b) Seen in plasma cell tumors

c) It is a marker of CML

d) Translocation of chromosome from 22 to 9

# Glycemic control over the previous 6-8 weeks in patients with diabetes mellitus is best assessed by estimation of : (COMEDK-08)

a) Fasting blood glucose

b) Glycated hemoglobin

c) Fasting C peptide

d) Fasting plasma insulin

# In Hemolytic anemia's the urobilinogen level in the blood would: (COMEDK-08)

a) Increase

b) Be absent

c) Decrease

d) Mildly decrease

# Gestational diabetes develops only during: (COMEDK-07)

a) Old age

b) Younger age

c) Pregnancy

d) Infancy 

# Shock lung is seen in: (COMEDK-08)

a) Hypovolemic shock

b) Septic shock

c) Anaphylactic shock

d) Neurogenic shock

# A 20 year female came to the medical OPD with severe pain and redness over dorsum of the foot. Past history of severe abdominal pain episodes was present. Peripheral smear showed anaemia with presence of poikilocytes. Likely diagnosis is: (COMEDK-08)

a) Hemoglobin C disease

b) Thalassemia minor

c) Sickle cell anemia

d) G6PD deficiency 

# Renal papillary necrosis is seen in: (KCET-08)

a) Sickle cell anaemia

b) Gouty nephropathy

c) Chronic glomerulo nephritis

d) Hypercalcaemia

# Which of the following is seen in secondary hyperparathyroidism ? (KCET-2011)

a) Chronic hypercalcaemia

b) Chronic hypocalcaemia

c) Chronic hypomagnaesemia

d) Chronic hypermagnaesemia

# Hypoparathyroidism is seen in all of the following except: (COMED-2012)

a) DiGeorge syndrome

b) Chronic renal failure

c) Wilsons disease

d) Haemochromatosis

# Hereditary spherocytosis, all are the true except: (AIPG-2011)

a) Increased osmotic fragility

b) Autosomal dominant disorder

c) Increased surface area to volume ratio

d) Direct coombs test is diagnostic

# Hypokalemia is likely to be seen in: (COMED-2012)

a) Insulin therapy

b) Addison's disease

c) Starvation ketosis

d) Hemolytic anemias

 # The prothrombin time is high in a patient with liver disease. However, the prothrombin time is normalized after the injection of vitamin K. This is a feature in: (COMEDK-09)

a) Severe hepatocellular disease

b) Chronic alcoholic liver disease

c) Deficiency of hepatic g-carboxylase

d) Cholestatic liver disease

 # All of the following occurs in adrenal deficiency except: (AIPG-10)

a) Hypoglycemia

b) Hypocalcemia

c) Hypotension

d) Hyponatremia 

# A 70 year old male is admitted to the hospital with a left hemiparesis and altered consciousness. He is on aspirin 75 mg OD, atrovostatin 10mg OD and glibenclamide 15mg daily. His wife says he has been unwell for a couple of days and he has been off food. He has however, still been giving him all his medications. Which of the following tests is going to be most useful in finding a immediately reversible cause for his symptoms? (KCET-2011)

a) Blood glucose levels

b) CT brain

c) ECG

d) Troponin levels

# Type I diabetes mellitus is associated with: (COMEDK-10)

a) insulin resistance

b) defect in mitochondrial DNA

c) islet cell autoantibodies

d) beta cell dysfunction

# Obesity is associated with all except: (AIIMS-09)

a) Growth Hormone deficiency

b) Thyroid hormone deficiency

c) Diabetes mellitus

d) Oestrogen deficiency

# The histologic criteria for diagnosis of acute appendicitis is neutrophilic infiltration of : (COMEDK-10)

a) Mucosa

b) Submucosa

c) Muscularis propria

d) Serosa 

# Good diabetic control is said to be present when glycosylated haemoglobin is:(KCET-09)

a) 7-9%

b) > 13%

c) 10-12%

d) 3-4%

# A 34 years old male presents with a history of thirst, polyuria and recent 3.2 kg weight loss. His urine contains a small amount of ketones. Which of the following would suggest he is most likely to have type 2 diabetes than type 1? (KCET-2012)

a) A BMI of 23

b) High circulating insulin levels

c) Positive islet cell antibodies

d) Plasma bicarbonate of 8 mmol/l

# Diamond blackfan anemia is another name of: (PGI-2011)

a) Inherited thrombocytopenia

b) Inherited leucopenia

c) Inherited erythroid aplasia

d) All

# A 41-year-old man presented to the emergency department with a 9-month history of cough, exertional dyspnea, nocturnal diaphoresis, and weight loss of 10 kg. The physical examination revealed painless, massive, discrete, rubbery cervical, supraclavicular and axillary lymphadenopathy. Plain radiography of the chest showed bilateral hilar lymphadenopathy. The serum calcium level was elevated at 16.2 mg per deciliter; serum parathyroid hormone is within normal range. The probable diagnosis of the above condition is:

a) Parathyroid carcinoma

b) Hyperthyroidism

c) Squamous-cell lung cancer

d) Hodgkin's lymphoma

# The best method of measuring the blood glucose level in the long term would be: (KAR -2013)

a) Glucose tolerance test

b) Benedict's test

c) Glycosylated-Hb method

d) Stressed glucose tolerance test

#Which of the following is NOT a cause for polyuria? (KAR -2013)

a) Excess fluid intake

b) Hyperglycemia

c) Hypokalemia

d) Hypocalcemia 

# A 41-year-old man presented to the emergency department with a 9-month history of cough, exertional dyspnea, nocturnal diaphoresis, and weight loss of 10 kg. The physical examination revealed painless, massive, discrete, rubbery cervical, supraclavicular and axillary lymphadenopathy. Plain radiography of the chest showed bilateral hilar lymphadenopathy. The serum calcium level was elevated at 16.2 mg per deciliter; serum parathyroid hormone is within normal range. The treatment regimen consists of

a) Chemotherapeutic regimen of doxorubicin, bleomycin, vinblastine, and dacarbazine

b) Anti tuberculosis regimen of INH, rifampicin, ethambutol and PAS

c) Linear radiation to the chest

d) Radial thyroidectomy and neck node dissection

# Hemoglobin electrophoresis is used as confirmatory test in which of the following anemias? (KAR -2013)

a) Iron deficiency anemia

b) Polycythemia

c) Hereditary spherocytosis

d) Sickle cell anemia

# One unit of packed RBC increases the blood hemoglobin by: (AIPG-2012)

a) 1 g/dl

b) 6-7 g/dl

c) 8-9 g/dl

d) None

# What is best replacement for factor VIII in hemophilia A? (AIPG-2012)

a) FFP

b) Cryoprecipitate

c) Whole blood

d) Factor VII

# A child is presenting features of hyperparathyroidism. All of the following are true about him except: (AIPG-2012)

a) Raised serum calcium

b) Raised serum phosphorus

c) Raised alkaline phosphatase

d) Resorption of minerals from bones

# A 41-year-old man presented to the emergency department with a 9-month history of cough, exertional dyspnea, nocturnal diaphoresis, and weight loss of 10 kg. The physical examination revealed painless, massive, discrete, rubbery cervical, supraclavicular and axillary lymphadenopathy. Plain radiography of the chest showed bilateral hilar lymphadenopathy. The serum calcium level was elevated at 16.2 mg per deciliter; serum parathyroid hormone is within normal range. A diagnostic investigation was performed on him:

a) FNAC of the mediastinal lymph node

b) Excisional biopsy of the axillary node

c) CT chest and abdomen

d) Core needle biopsy of the neck node

# Diabetes is associated with all of the following in the elderly EXCEPT: (KAR -2013)

a) Cerebrovascular accident

b) Cognitive decline 

c) Myocardial infarction

d) None of the above

# Leucocyte common antigen is seen in? (AIPG-14)

a) Lymphoma

b) Ewing sarcoma

c) Rhabdomyosarcoma

d) Osteosarcoma

# Measurement of HbA1C is required for? (AIPG-14)

a) Screening of controlled diabetes

b) Monitoring of diabetes

c) Screening of uncontrolled diabetes

d) Confirmation of diabetes

# Lymph nodes of which area are not easily palpable? (AIPG-14)

a) Axilla

b) Neck

c) Groin

d) Abdomen

#  Localization of parathyroids in hyperparathyroidism is done best with: (COMEDK -2013)

a) X ray neck

b) USG neck

c) I131 scan

d) Technetium 99 labelled sestamibi scan

# In intracerebral haemorrhage the size of haemorrhage can be reduced by: (NEET -2013)

a) Factor VIII

b) Factor V

c) Factor X

d) Factor VII

# AB -ve girl should be given blood, which blood group can be given in case of non-availability of her blood? (NEET -2013)

a) A (-ve)

b) B (-ve)

c) O (-ve)

d) AB (+ve)