Excessive segmentation of nucleus of neutrophils

# Excessive segmentation of nucleus of neutrophils is a manifestation of ?
A. Folate or vitamin B12 deficiency
B. Iron deficiency
C. Thalassemia
D. Repeated blood transfusion

The correct answer is: A. Folate or vitamin B12 deficiency.

Nucleus of neutrophils normally contains up to four segments. Excessive segmentation (>5

nuclear lobes) is seen in folate or vitamin B12 deficiency & congenital neutropenia syndrome of

warts, hypogammaglobulinemia, infections & myelokathexis (WHIM).

Ref: Harrison’s 18th Ed. 473