# What are the most difficult teeth to anesthetize with irreversible pulpitis?
a. maxillary molars
b. mandibular molars
c. maxillary anterior teeth
d. maxillary premolars
With irreversible pulpitis, the teeth most difficult to anesthetize are the mandibular molars, followed by (in order) the mandibular and maxillary premolars, maxillary molars, mandibular anterior teeth, and maxillary anterior teeth.
Ref: Endodontics Principles and Practice, Torabinejad, Fifth Edition, Page e26
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