# Which of the following can be given safely in pregnancy?
a. Imatinib
b. Heparin
c. Warfarin
d. Thalidomide
The correct answer is B. Heparin.
Human Teratogenic Drugs - Drugs causing human birth defect
Thalidomide – Phocomelia, multiple defects
All anticancer drugs – Multiple defects, fetal death
Androgens – Virilization, limb, esophageal, cardiac defects
Progestins – Virilization of female fetus
Tetracycline – Discolored and deformed teeth, retarded bone growth
Warfarin – Nose, eye and hand defects, growth retardation
Phenytion – Hypoplastic phalanges, cleft lip/palate microcephaly
Phenobarbitone – Various malformations
Chlorpromazine – Neural tube defects
Valproate sodium – Spina bifida and other normal tube defects
Lithium – Fetal goitre, cardiac and other abnormalities
Isotretinoin – Craniofacial, heart and CVS defects
Imatinib – Multiple defects exomphalos, kidney abnormalities
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