‘Chicken-wire’ appearance of enlarged bone marrow spaces is seen in:

 # ‘Chicken-wire’ appearance of enlarged bone marrow spaces is seen in:

A. Fetal alcohol syndrome

B. Sickle cell anemia

C. Hemophilia A

D. Beta thalassemia major

The correct answer is D. Beta thalassemia major.

Radiographic changes of thalassemia include generalized rarefaction of alveolar bone, chicken-wire appearance of enlarged marrow spaces and coarse trabeculation. In the skull, proliferation of marrow may completely erode the cortex, leaving only periosteum, and produce a ‘hair-on-end’ radiographic appearance.

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