HSV-2 virus resides in:

 # HSV-2 virus resides in:

A. Basal ganglia

B. Stellate ganglia

C. Lumbosacral ganglion

D. Otic ganglion

The correct answer is C. Lumbosacral region.

It is now well established that the HSV does not remain latent at the site of the original infection in the skin or oral mucosa. Instead, the virus reaches nerve ganglia supplying the affected areas, presumably along nerve pathways, and remains latent there until reactivated. The usual ganglia involved are the trigeminal for HSV-1 and the lumbosacral for HSV-2. Viral DNA can be demonstrated in these ganglia. Unfortunately, this incorporation of viral DNA into host DNA ensures a lifelong infection beyond the reach of antibody, cell mediated immune responses or chemotherapy.