# Atherosclerosis is due to
a. HDL receptor defect
b. apolipoprotein E deficiency
c. decreased LDL activity
d. decreased lipoprotein lipase
The correct answer is B. Apolipoprotein E deficiency.
Apolipoprotein (apo) E is recognized for its unparalleled ability to suppress atherosclerosis .The expression of apoE in the macrophage has long been recognized to suppress atherosclerosis by preventing foam cell formation in the vessel wall.
APOE was initially recognized for its importance in lipoprotein metabolism and cardiovascular disease. Defects in APOE result in familial dysbetalipoproteinemia aka type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron, VLDL and LDL.
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