The reversal agent used in clinical practice to treat benzodiazepine overdose:

 The reversal agent used in clinical practice to treat benzodiazepine overdose

A. Romazicon 

B. Naloxone

C. Sublimaze

D. Demerol

The correct answer is A. Romazicon.

-Flumazenil (Romazicon) is a direct, specific reversal agent used in clinical practice to treat benzodiazepine overdose. Pharmacologically, it acts as a competitive antagonist at the benzodiazepine receptor sites in the CNS. 

-Naloxone is a life-saving medication that can reverse an overdose from opioids, including heroin, fentanyl, and prescription opioid medications.

-Fentanyl (Sublimaze) is a potent synthetic opiate agonist. A dose of 0.1 mg is approximately equivalent to 10 mg of morphine or 75 mg of meperidine. Fentanyl acts rapidly, and after intramuscular injection the onset occurs in 7–15 min; duration of effects is 1– 2 h.

-Meperidine (Demerol) is a synthetic opiate agonist, closely related to fentanyl in chemical structure.

Reference: Mc Donald 2nd South Asian Edition