Which of the following statements applies to globular dentin?

 # Which of the following statements applies to globular dentin? 

a. Deposited first along the dentinoenamel junction. 

b. Mineralized by matrix vesicles. 

c. Separates mantle dentin from circumpulpal dentin. 

d. Secreted by immature odontoblasts. 

The correct answer is C. Separates mantle dentin from circumpulpal dentin.

Sometimes mineralization of dentin begins in small globular areas that fail to coalesce into a homogeneous mass. This results in zones of hypomineralization between the globules. These zones are known as globular dentin or interglobular spaces. This dentin forms in the crowns of teeth in the circumpulpal dentin just below the mantle dentin, and it follows the incremental pattern. The dentinal tubules pass uninterruptedly through interglobular dentin, thus demonstrating defect of mineralization and not of matrix formation.