Histologically, presence of numerous mast cells is diagnostic feature of:

 # Histologically, presence of numerous mast cells is diagnostic feature of:

a. Fibroma

b. Neurofibroma

c. Traumatic neuroma

d. Malignant Peripheral Nerve Sheath Tumor

The correct answer is B. Neurofibroma.

Solitary and multiple neurofibromas have the same microscopic features. They contain spindle-shaped

cells, with fusiform or wavy nuclei found in a delicate connective tissue matrix; this matrix may be notably myxoid in character. Lesions may be well circumscribed or may blend into surrounding connective tissue. Mast cells are characteristically scattered throughout the lesion. A histologic subtype

known as plexiform neurofibroma is regarded as highly characteristic of neurofibromatosis. In this variety, a collagen matrix supports extensive interlacing masses of nerve tissue. Small axons may be seen among the proliferating Schwann cells and perineural cells.