The term poikilokaryosis refers to :

 # The term poikilokaryosis refers to :

A. Alteration of nuclear cytoplasmic ratio

B. large, prominent nucleii

C. division of nuclei without division of cytoplasm

D. loss of polarity and disorientation of cells

The correct answer is C. Division of nuclei without division of cytoplasm.

Criteria for diagnosis of epithelial dysplasia in carcinoma include: 

• Increased abnormal mitoses 

• Individual cell keratinisation 

• Epithelial pearls in the spinous layer 

• Alterations in nuclear Cytoplasmic ratio 

• Loss of polarity and disorientation of cells 

• Hyper chromatism 

• Large nucleoli 

• Dyskaryosis or nuclear atypism including giant nuclei. 

• Poikilokarynosis or division of nuclei without division of cytoplasm 

• Basilar hyperplasia Individual cell keratinisation and epithelial pearl formation is absent in carcinoma in situ or intra epithelial carcinoma.