The glycoprotein antigen chiefly detected in pemphigoids is:

 # The glycoprotein antigen chiefly detected in pemphigoids is: 

A. BP 180 and 230 

B. DSG 2 and 3 

C. BP 130 and 280 

D. DSG 1 and 4 

The correct answer is A. BP 180 and 230.

Bullous Pemphigoid is an autoimmune disease caused by the binding of autoantibodies to specific antigens found in the lamina lucida region of the basement membrane on the hemidesmosomes of epithelial basal cells. These antigens are glycoproteins referred to as bullous pemphigoid antigens, BP 180 and BP 230. Binding of antibody to antigen activates both leukocytes and complement, causing localized damage to the basement membrane, resulting in vesicle formation in the subepithelial region.