# The pathological state that alters the volume of distribution of many drugs is:

  # The pathological state that alters the volume of distribution of many drugs is:

A. Septicemia

B. Duodenal ulcers

C. Congestive heart failure

D. Hypertension

The correct answer is C. Congestive heart failure.

In congestive heart failure the volume distribution is often decreased by 40% and loading doses of drugs should be appropriately reduced. Drug clearance may also be diminished due to decreased blood flow to the liver and kidneys.