Oral contraceptive failure occurs in a patient on Rifampicin because of:

 # Oral contraceptive failure occurs in a patient on Rifampicin because of:

A. Rifampicin induces the metabolism of contraceptive

B. Rifampicin stimulates gonadotropin release from the pituitary

C. Rifampicin decreases the secretion of progestin

D. Rifampicin antagonizes the action of oral contraceptives

Contraceptive failures can be minimized by using an oral contraceptive containing a higher dose of estrogen or by using an alternative method of contraception. Induction of liver enzymes means that concomitant drug treatment may be made less effective. Oral contraception will not be effective, so alternative birth-control methods should be used.