Some microorganisms produce a diffuse spreading inflammatory reaction due to the elaboration of:

 # Some microorganisms produce a diffuse spreading inflammatory reaction due to the elaboration of:

A. Coagulase

B. Peroxidase

C. Bradykinin

D. Hyaluronidase

The correct answer is D. Hyaluronidase.

Hyaluronidase is an enzyme produced by some microorganisms, such as Streptococcus, that can break down hyaluronic acid. Hyaluronic acid is a component of the connective tissue in the body, and its degradation by hyaluronidase can lead to the spread of inflammatory reactions by increasing permeability of tissues and facilitating the spread of the microorganisms through the host's tissues. This can contribute to the diffuse spreading of inflammation.