A 5 year old child is diagnosed with leukocyte adherence deficiency and is also affected with generalized severe bone loss adjacent to his primary teeth. What is the diagnosis?

 # A 5 year old child is diagnosed with leukocyte adherence deficiency and is also affected with generalized severe bone loss adjacent to his primary teeth. What is the diagnosis?

A. Generalized aggressive periodontitis

B. Generalized chronic periodontitis

C. Gingival diseases modified by systemic factors

D. Periodontitis as a manifestation of systemic disease

The correct answer is D. Periodontitis as a manifestation of systemic disease.

Leukocyte adhesion deficiency (LAD) is a rare immunodeficiency disorder that impairs the body's ability to fight infection. This condition is associated with early, severe periodontitis due to the inability of leukocytes (white blood cells) to migrate to infection sites, leading to impaired immune responses and increased susceptibility to bacterial infections. The severe bone loss around the primary teeth is a manifestation of this systemic disease. Therefore, the periodontitis is secondary to the systemic condition, which makes D the most appropriate choice.