# Anti caries vaccine is based on which immunoglobulin?
A. IgA
B. IgE
C. IgM
D. IgG
The correct answer is A. IgA.
The major immunoglobulin in saliva is secretory IgA. whereas IgG, which comprises about 80% of the total immunoglobulin in serum, is found only in low level in salivary secretions. The molecular configuration renders the secretory IgA antibody exceptionally resistant to digestion by proteolytic enzymes. Consequently, it can function highly effectively in an oral environment which contains microbial proteases. Salivary IgA plays an important role in the defense of the host against colonization of streptococci by agglutination of the organisms.
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