Increased ketone bodies are seen in:

  # Increased ketone bodies are seen in:

1. Uncontrolled diabetes

2. Protein deficiency

3. Well fed state

4. Prolonged starvation

A. 2 and 4

B. 1, 2 and 3

C. 1 and 2

D. 1 and 4

The correct answer is D. 1 and 4.

1. Uncontrolled diabetes: In uncontrolled diabetes, especially type 1 diabetes, there is a lack of insulin, leading to increased lipolysis and subsequent production of ketone bodies, resulting in diabetic ketoacidosis. 

4. Prolonged starvation: During prolonged starvation, the body depletes its glucose stores and starts breaking down fats, leading to an increase in ketone bodies for energy. 

2. Protein deficiency (Incorrect) 

Protein deficiency does not typically lead to an increase in ketone bodies. 

3. Well-fed state (Incorrect) 

In a well-fed state, the body has sufficient glucose for energy, so ketone body production is minimal.