Endocrine disorder is the primary cause of:

 # Endocrine disorder is the primary cause of:

A. Acromegaly

B. Albright’s syndrome

C. Paget’s disease

D. Fibrous dysplasia

The correct answer is A. Acromegaly.

Explanation:

Acromegaly is primarily caused by an endocrine disorder, specifically excess growth hormone (GH) secretion, usually due to a pituitary adenoma. This leads to abnormal growth of bones and soft tissues, particularly in adults.

Other options explained:

B. Albright’s syndrome (McCune-Albright Syndrome): A genetic disorder caused by post-zygotic mutations in the GNAS gene, leading to fibrous dysplasia, café-au-lait spots, and endocrine abnormalities. It is not primarily an endocrine disorder but has endocrine manifestations.

C. Paget’s disease: A bone remodeling disorder of unclear etiology, possibly involving genetic and environmental factors, not primarily endocrine.

D. Fibrous dysplasia: A developmental bone disorder caused by activating mutations in the GNAS gene, not related to endocrine dysfunction as a primary cause.