# True about Philadelphia chromosome is:
A. Seen in CML
B. Due to reciprocal translocation from chromosome 9 to 22 and vice versa
C. It is a prognostic feature
D. All of the above
The correct answer is D. All of the above.
Chronic Lymphocytic thyroiditis refers to:
# Chronic Lymphocytic thyroiditis refers to:
a) Tuberculous thyroiditis
b) Hashimoto's thyroiditis
c) Dequervain's thyroiditis
d) Riedel's thyroiditis
The correct answer is B. Hashimoto's Thyroiditis.
Hashmimoto's thyroiditis:
• Most common type of thyroiditis
• Autoimmune; raised titres of thyroid antibodies.
• Mild hyperthyroidism may be present initially but hypothyroidism is inevitable.
• Characteristic 'bosselated' feel with soft, rubbery or firm in consistency; Hurthle cells present.
Auer bodies are a characteristic of:
# Auer bodies are a characteristic of:
A. Plasma cells
B. Monocytes
C. Myeloblasts
D. Reticulocytes
A. Plasma cells
B. Monocytes
C. Myeloblasts
D. Reticulocytes
The correct answer is C. Myeloblasts.
Myeloblasts may have intracytoplasmic rods (stain red) called Auer rods. Auer rods are abnormal lysosomes (primary granules) that are pathognomic of myeloblasts and not found in ALL. Auer rods also stain positive with myeloperoxidase. The diagnosis of AML is established by the presence of >20% myeloblasts in blood and/or bone marrow. A positive myeloperoxidase reaction in >3% of the blasts may be the only feature distinguishing AML from acute lymphoblastic leukemia (ALL).
G6PD Deficiency causes
# Glucose-6-phosphate dehydrogenase deficiency causes:
A. Haemophilia
B. Hemolytic anaemia
C. Aplastic anaemia
D. Megaloblastic anaemia
The correct answer is B. Hemolytic anemia.
The red blood cells are well protected against oxidation because of adequate generation of reduced glutathione. Individuals with G6PD deficiency (an enzyme required for hexose monophosphate shunt / HMP shunt for glucose metabolism) fail to develop adequate levels of reduced glutathione in their red cells and this results in oxidation and precipitation of hemoglobin within the red cells forming "HEINZ BODIES"
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A. Haemophilia
B. Hemolytic anaemia
C. Aplastic anaemia
D. Megaloblastic anaemia
The correct answer is B. Hemolytic anemia.
The red blood cells are well protected against oxidation because of adequate generation of reduced glutathione. Individuals with G6PD deficiency (an enzyme required for hexose monophosphate shunt / HMP shunt for glucose metabolism) fail to develop adequate levels of reduced glutathione in their red cells and this results in oxidation and precipitation of hemoglobin within the red cells forming "HEINZ BODIES"
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