Epithelioid cells and giant cells are derived from

# Epithelioid cells and giant cells are derived from macrophages and are important in the development of:
A. Initial inflammation
B. Granulomatous inflammation
C. Acute inflammation
D. Subacute inflammation

The correct answer is B. Granulomatous inflammation.

Granulomatous inflammation is a subtype of chronic inflammation and is characterized by granulomas, which are nodular collections of specialized macrophages referred to as epithelioid cells. A rim of lymphocytes usually surrounds granulomas. Granulomas are produced by multinucleated giant cells (Langerhans giant cells and foreign body giant cells). All the other cell types characteristic of chronic inflammation, including plasma cells, eosinophils, and fibroblasts, may also be associated with granulomas.

Note: Granulomatous inflammation is characteristically associated with areas of caseous necrosis produced by infectious agents, particularly Mycobacterium tuberculosis.

• Tuberculosis: caused by the inhalation of Mycobacte1ium tuberculosis. Oral non-healing chronic ulcers follow lung infection. Important: Characterized by caseating granulomas with multinucleated giant cells (Langerhans giant cells and foreign body giant cells).

Etiologic agents associated with granulomatous inflammation:

• Infectious agents

- TB and leprosy, which are mycobacterial diseases

- Fungal infections (blastomycosis, histoplasmosis, and coccidioidomycosis)

- Spirochetes (Treponema pallidum, which causes syphilis)

- Cat scratch disease (caused by an unnamed gram-negative organism)

• Foreign material (e.g., suture or talc)

• Sarcoidosis (unknown etiology; it is non-necrotizing)

• Crohn's disease (it is non-caseating)

Hepatitis found only in patients with acute or chronic episodes of Hepatitis B

# Which type of Hepatitis is found only in patients with acute or chronic episodes of Hepatitis B?
A. Hepatitis C
B. Hepatitis D
C. Hepatitis E
D. Hepatitis A

The correct answer is B. Hepatitis D, this virus causes "serum" or long-incubation hepatitis

The Hepatitis B virus (HBV) is a double-stranded DNA virus with worldwide distribution, transmitted by parenteral and sexual contact. Risk factors include multiple sexual partners, intravenous drug abuse, and receipt of blood products. Its incubation period is 40 to 100 days, and it can be recovered from all body fluids, most importantly, blood, breast milk, and amniotic fluid. The signs and symptoms are similar to hepatitis A (leve1; abdominal pain, nausea, etc.) but there is a longer incubation period (6-8 weeks). The symptoms are slower in developing but are of a longer duration. Most patients recover fully, however, some develop chronic liver disease.

Previously, viral hepatitis that was not caused by the type A or type B virus was called "non-A, non-B hepatitis." Recently three more viruses have been identified that cause some of these non-A, non-B infections.

These new viruses include:

• Hepatitis C: is a serum hepatitis that is caused by a virus antigenically different from Hepatitis viruses A and B. Most cases of post-transfusion hepatitides are of this type. It is usually much milder than A or B but is otherwise clinically indistinguishable from them. There is a higher incidence of chronic disease (chronic hepatitis), cirrhosis, and hepatocellular carcinoma. Note: Hepatitis C is now the most common reason for liver transplantation in the U.S.

• Hepatitis D: is found only in patients with acute or chronic episodes of Hepatitis B, and it makes the Hepatitis B infection more severe. Drug addicts are at relatively high risk.

• Hepatitis E: is transmitted enterically, much like Hepatitis A. It causes occasional epidemics similar to those caused by Hepatitis A. So far these epidemics have occurred only in underdeveloped countries.

Disease associated with a decreased incidence of dental caries

# Which of the following diseases is associated with a decrease in caries?
A. Sjogren's syndrome
B. Cystic fibrosis
C. Cerebral palsy
D. Down syndrome

The correct answer is B. Cystic fibrosis.

** Important: There is a significantly reduced caries rate in patients with cystic fibrosis. This is probably the result of alterations in saliva and the long-term use of antibiotics. Cystic fibrosis is a congenital metabolic disorder that causes the exocrine glands (which are glands that secrete fluids into a duct) to produce abnormal secretions, resulting in several symptoms, the most important of which affect the digestive tract and the lungs. In some glands, such as the pancreas and those in the intestines, the secretions are thick or solid {an excessively viscous mucous) and may block the gland completely. The mucous producing glands in the airways of the lungs produce abnormal secretions that clog the airways and allow bacteria to multiply. The sweat glands secrete fluids that have high sodium and chloride content. Note: The staining of the teeth is most likely due to the fact

that patients with cystic fibrosis are usually subjected to large amounts of tetracyclines during childhood.

Symptoms of CF include:

• Poor growth despite a good appetite

• Malabsorption and foul, bulky stools: steatorrhea

• Chronic bronchitis (COPD) with cough

• Recurrent pneumonia: respiratory infections

• Clubbing of fingers and toes

• Barrel-chested appearance 

Severe hypothyroidism in a child

# Severe hypothyroidism in a child is called:
A. Dwarfism
B. Myxedema
C. Cretinism
D. Acromegaly

The correct answer is C. Cretinism.

Hypothyroidism refers to a condition in which the amount of thyroid hormone in the body is below normal. This is the most common form of thyroid function abnormality and is far more common than hyperthyroidism. This condition is considerably more common in women than in men. The most common cause of hypothyroidism is Hashimoto's thyroiditis.

The second most common cause is the treatment of hyperthyroidism. Hypothyroidism is characterized by the puffiness of the face and eyelids and swelling of the tongue and larynx. The skin becomes dry and rough and the hair becomes sparse. The individual has a low basal-metabolic rate and a low body temperature. The affected individuals also have poor muscle tone, low strength and get tired very easily. Mentally they are very sluggish. The treatment of hypothyroidism is straight forward and consists of administering thyroid hormone (thyroxin).

Severe hypothyroidism in a child is called cretinism. Due to a lack of thyroid hormone, there is a retardation of growth and abnormal development of bones. Mental retardation is caused by the improper development of the CNS. If this condition is recognized early, it can be markedly improved with the use of thyroid hormones. Note: Extreme hypothyroidism in adults is called myxedema.

Note: Dental findings in a child with hypothyroidism include an underdeveloped mandible with an overdeveloped maxilla, enlarged tongue which may lead to malocclusion, delayed eruption of teeth, and deciduous teeth being retained longer.

Treatment of Parathyroid hormone deficiency

# A deficiency of parathyroid hormone can be treated with:
A. Vitamin A
B. Vitamin C
C. Vitamin D
D. Vitamin K

The correct answer is C. Vitamin D.

Hypoparathyroidism is a rare disorder associated with insufficient production of parathyroid hormone, the inability to make a usable form of parathyroid hormone or the inability of kidneys and bones to respond to parathyroid hormone production.

Hypoparathyroidism can result from congenital disorders, iatrogenic causes (e.g., drugs, removal of the parathyroid glands during thyroid or parathyroid swge1y. radiation), infiltration of the parathyroid glands (e.g., metastatic carcinoma. Wilson disease, sarcoid), suppression of parathyroid function, HIV/AIDS, or idiopathic mechanisms.

Hypocalcemia is the most important consequence of hypoparathyroidism. Symptoms occur when ionized calcium level drops to less than 2.5-3 mg/1 00 mL. The clinical manifestation is tetany. A positive Chvostek's sign (twitching of the facial muscles when tapped on the facial nerve near the parotid gland) is characteristic of hypoparathyroidism.

Important: The dental manifestations of hypoparathyroidism (i.e., delayed eruption. enamel hypoplasia and blunted root apices) may be prevented by early treatment with vitamin D.

Cleft Palate occurs during which week of gestation?

# Cleft palate occurs in the ___________ of embryonic life.
A. First to third week
B. Fourth to sixth week
C. Eighth to tenth week
D. Twelfth to fourteenth week

The correct answer is C. 8th to 10th week.

Cleft palate occurs in the eighth to tenth week of embryonic life. Isolated clefts of the palate are more common in females. It is characterized by a fissure in the midline of the palate, resulting from the failure of the two sides to fuse during embryonic development.

The most severe handicap imposed by cleft palate is an impaired mechanism preventing normal speech and swallowing. 

Note: It affects approximately 1 in 2000 births.

Cleft lip results when the medial nasal process fails to fuse with the lateral portions of the maxillary process of the first branchial arch. Fusion normally occurs during the sixth and seventh weeks of embryonic development. The maxillary lip is most commonly affected.

It may be bilateral (20%) or unilateral (80%). Clefts of the lip are more frequent in males. Lip cleft involvement is more frequent on the left side than the right.

Note: It affects approximately 1 in 1000 births, but varies with race.

Leukemia most common in children

# Leukemias are evenly split between the acute and chronic forms, but among children one form accounts for about two-thirds of cases. This one form is:
A. Acute lymphocytic leukemia (ALL)
B. Acute myeloid leukemia (AML)
C. Chronic lymphocytic leukemia (CLL)
D. Acute monoblastic

The correct answer is A. Acute lymphocytic leukemia (ALL).

The peak age for ALL is around four years old, and it is the form of acute leukemia that is the most responsive to therapy. Current therapies for ALL include chemotherapy with follow-up radiation and possible bone-marrow transplant after particularly high dose chemotherapy treatment or in cases of recurrence or if it is non-responsive to other treatments.

*** Acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL) are the most common types in adults.

Although the exact cause of most leukemias remains unknown, increasing evidence suggests a combination of contributing factors. These factors include: familial tendency, congenital disorders (Down syndrome, or the presence of Philadelpltia chromosome -chronic myeloid leukemia), viruses (e.g., HTLVI, herpes-like viral particles have been cultured from patients and leukemic patients have high antibody titer to the Epstein-Barr virus), ionizing radiation and the exposure to the chemical benzene and cytotoxins such as alkylating agents.

Important: Oral lesions are most likely to be observed in myelogenous leukemia. These oral lesions may be the initial manifestation of the disease. The oral lesions include gingivitis, gingival hemorrhage, generalized gingival hyperplasia. petechiae, ecchymoses, and ulcerations.