Excessive segmentation of nucleus of neutrophils

# Excessive segmentation of nucleus of neutrophils is a manifestation of ?
A. Folate or vitamin B12 deficiency
B. Iron deficiency
C. Thalassemia
D. Repeated blood transfusion

The correct answer is: A. Folate or vitamin B12 deficiency.

Nucleus of neutrophils normally contains up to four segments. Excessive segmentation (>5

nuclear lobes) is seen in folate or vitamin B12 deficiency & congenital neutropenia syndrome of

warts, hypogammaglobulinemia, infections & myelokathexis (WHIM).

Ref: Harrison’s 18th Ed. 473

Contraindication for splenectomy

# Which out of the following is a contraindication for splenectomy ?
A. Iatrogenic splenic rupture
B. Thrombocytopenia
C. Presence of bone marrow failure
D. Hairy cell leukemia

The correct answer is C. Presence of bone marrow failure.

The only contraindication to splenectomy is the presence of marrow failure, in which the

enlarged spleen is the only source of hematopoietic tissue.

Ref: Harrison’s 18th Ed. 471

Weight of Normal Spleen

# Weight of a normal spleen is ?
A. < 150 grams
B. < 250 grams
C. < 350 grams
D. < 450 grams

The correct answer is B. < 250 grams.

Normal spleen weighs <250 grams.

Ref: Harrison’s 18th Ed. 468

Enlarged, grayish yellow or orange tonsils are pathognomic of

# Enlarged, grayish yellow or orange tonsils are pathognomic of ?
A. Waldenström’s macroglobulinemia
B. Polycythemia vera
C. Wolman disease
D. Tangier disease

The correct answer is D. Tangier Disease.

Tangier disease is associated with cholesterol accumulation in reticuloendothelial system with

hepatosplenomegaly & enlarged, grayish yellow or orange tonsils.

Ref: Harrison’s 18th Ed. 3154

Preauricular lymphadenopathy

# Preauricular lymphadenopathy accompanies which of the following?
A. Scalp infection
B. Ear infection
C. Conjunctival infections
D. Tooth infection

The correct answer is: C. Conjunctival infections.

Preauricular adenopathy accompanies conjunctival infections and cat-scratch disease.

Ref: Harrison’s 18th Ed. 466

Occipital lymphadenopathy

# Occipital lymphadenopathy accompanies which of the following ?
A. Scalp infection
B. Ear infection
C. Conjunctival infections
D. Tooth infection

The correct answer is : A. Scalp infection.

Occipital adenopathy often reflects infection of the scalp.

Ref: Harrison’s 18th Ed. 466

Platelet count rise at what time of menstrual cycle?

# During menstrual cycle, platelet count rise at what time ?
A. Following ovulation
B. At the onset of menses
C. After completion of menstrual flow
D. Before ovulation

The correct answer is A. Following ovulation.

Platelet count varies in menstrual cycle, rising following ovulation & falling at onset of menses.
Ref: Harrison’s 16th Ed. 673