# ________ is fibrous, insoluble protein derived from epidermis.
A. Collagen
B. Keratin
C. Elastin
D. Myofibril
The correct answer is B. Keratin.
Keratin is fibrous and insoluble protein derived from epidermnis. Elastin is rich in proline and other non polar side chains. Approximately one third of elastin is composed of amino acid glycine.
C. A drug needed for treatment or prevention of a rare disease
D. A drug which acts on Orphanin receptors
The correct answer is C. A drug needed for treatment or prevention of a rare disease.
Orphan Drugs These are drugs or biological products for diagnosis/treatment/ prevention of a rare disease or condition, or a more common disease (endemic only in resource poor countries) for which there is no reasonable expectation that the cost of developing and marketing it will be recovered from the sales of that drug. The list includes sodium nitrite, fomepizole, liposomal amphotericin B, miltefosine, rifabutin, succimer, somatropin, digoxin immune Fab (digoxin antibody), liothyronine (T3) and many more. Though these drugs may be life saving for some patients, they are commercially difficult to obtain as a medicinal product. Governments in developed countries offer tax benefits and other incentives to pharmaceutical companies for developing and marketing orphan drugs (e.g. Orphan Drug Act in USA).
NYSTATIN: Obtained from S. noursei, it is similar to Amphotericin B (AMB) in antifungal action and other properties. However, because of higher systemic toxicity, it is used only locally in superficial candidiasis.
Given orally, it is not absorbed; can be used for monilial diarrhoea (due to superinfection or otherwise), 5 lac U TDS (1 mg = 2000 U). Nausea and bad taste in mouth are the only side effects.