# Pathological calcification is seen in: A. Scleroderma B. Lichen planus C. Dystrophic epidermolysis bullosa D. Lupus erythematosus The correct answer is A. Scleroderma. Pathologic calcification is a common process in a wide variety of disease states; it implies the abnormal deposition of calcium salts, together with smaller amounts of iron, magnesium, and other minerals. When the deposition occurs in dead or dying tissues, it is called dystrophic calcification; it occurs in the absence of derangements in calcium metabolism (i.e., with normal serum levels of calcium). In contrast, the deposition of calcium salts in normal tissues is known as metastatic calcification and is almost always secondary to some derangement in calcium metabolism (hypercalcemia). Of note, while hypercalcemia is not a prerequisite for dystrophic calcification, it can exacerbate it. Systemic sclerosis can be classified into two groups on the basis of its clinical course: • Diffuse scleroderma, characterized ...