# Which has common role in osteoblast, fibroblast and cementoblast? A. Osteopontin B. Osteocalcin C. Osteogenin D. Bone Sialoprotein The correct answer is A. Osteopontin. Osteopontin (OPN) is a highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. Osteopontin (OPN), also known as bone sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). Osteopontin is biosynthesized by a variety of tissue types including fibroblasts preosteoblasts, osteoblasts, osteocytes, odontoblasts, some bone marrow cells, hypertrophic chondrocytes, dendritic cells, macrophages, smooth muscle, skeletal muscle myoblasts, endothelial cells and extraosseous (non-bone) cells in the inner ear, brain, kidney, deciduum and placenta. CLICK HERE FOR MORE MCQs...