Vacancy for Dental Surgeon and Dental Hygienist Jobs in Nepal - Vacancy for Dentists and Dental Hygienists - NMC registered Dental Surgeons and NHPC registered Dental Hygienists

1. Dentist

Apply Before: 31st January 2023

Basic Job Information

No. of Vacancy/s : 1

Apply Before(Deadline) : Jan. 31, 2023

Job Specification

Education Level : Bachelor in Dental Surgery (BDS)

Experience Required : More than 2 years

Dentist

Himalayan Trust Nepal (HTN) is hiring a qualified Dentist to work at Namche Dental Clinic located in Namche Bazar Solukhumbu. The clinic is supported by the American Himalayan Foundation and managed by HTN in partnership with the Namche Dental Clinic Management Committee.

Job responsibility: This position holder is responsible to provide dental health services to local residents and visitors.

Qualification: BDS degree with a license from Nepal Medical Council and minimum work experience of 2 years with good written and verbal communication in English and Nepali. A good level of physical fitness to live and work at a high altitude is preferred.

Gross salary: Rs. 90,000/month including tax. The clinic operates only 9 months a year, but the job holder will get 12 months' salary. Food and accommodation will be provided.

Contract period: Initial one-year contract and will be renewed annually. Starting Date: 1 March 2023

Application Deadline: 31 January 2023

Interview Date: 8 February 2023 (for short-listed candidates only)

Please keep visiting this page for latest vacancies for Dental surgeons and Dental hygienists available in Nepal.

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Histologically, presence of numerous mast cells is diagnostic feature of:

 # Histologically, presence of numerous mast cells is diagnostic feature of:

a. Fibroma

b. Neurofibroma

c. Traumatic neuroma

d. Malignant Peripheral Nerve Sheath Tumor

The correct answer is B. Neurofibroma.

Solitary and multiple neurofibromas have the same microscopic features. They contain spindle-shaped

cells, with fusiform or wavy nuclei found in a delicate connective tissue matrix; this matrix may be notably myxoid in character. Lesions may be well circumscribed or may blend into surrounding connective tissue. Mast cells are characteristically scattered throughout the lesion. A histologic subtype

known as plexiform neurofibroma is regarded as highly characteristic of neurofibromatosis. In this variety, a collagen matrix supports extensive interlacing masses of nerve tissue. Small axons may be seen among the proliferating Schwann cells and perineural cells.

Mandible is the common site for Ameloblastoma due to:

 # Mandible is the common site for Ameloblastoma due to:

a. SMO mutation

b. BRAF mutation

c. p53 mutation

d. SH3BP2 mutation

The correct answer is B. BRAF mutation.

Mutations in the oncogenes BRAF (kinase signaling pathway) in mandibular tumors and SMO (hedgehog signaling pathway) in maxillary tumors have been discovered in a large proportion of

ameloblastomas. Drugs developed to inhibit the mutated proteins of these genes may have a role in the future treatment of ameloblastomas. Mutations of the p53 gene do not appear to play a role in the development and growth of ameloblastoma; a role for ameloblastin protein has been identified, although it is not specific to ameloblastoma.

Addison's disease is due to:

 # Addison's disease is due to:

a. Chronic insufficiency of adrenal cortex

b. Chronic insufficiency of adrenal medulla

c. Insufficiency of pancreas

d. Hypofunction of thyroid gland

The correct answer is A. Chronic insufficiency of adrenal cortex.

Addison's disease, also known as primary adrenal insufficiency, is a rare long-term endocrine disorder characterized by inadequate production of the steroid hormones cortisol and aldosterone by the two outer layers of the cells of the adrenal glands (adrenal cortex), causing adrenal insufficiency. Symptoms generally come on slowly and insidiously and may include abdominal pain and gastrointestinal abnormalities, weakness, and weight loss. Darkening of the skin in certain areas may also occur. Under certain circumstances, an adrenal crisis may occur with low blood pressure, vomiting, lower back pain, and loss of consciousness. Mood changes may also occur. Rapid onset of symptoms indicates acute adrenal failure which is a serious and emergent condition. An adrenal crisis can be triggered by stress, such as from an injury, surgery, or infection. 

The mitochondrial enzyme involved in the metabolism of clopidogrel and proton pump inhibitors is:

 # The mitochondrial enzyme involved in the metabolism of clopidogrel and proton pump inhibitors is:

a. CYP 2A

b. CYP 2B

c. CYP 2C19

d. CYP 2C20

The correct answer is C. CYP 2C19.

Like ticlopidine, clopidogrel is also a prodrug. About 50% of the ingested dose is absorbed, and

only a fraction of this is slowly activated in liver by CYP2C19, while the rest is inactivated by other enzymes. It is a slow acting drug; antiplatelet action takes about 4 hours to start and develops over days. Since CYP2C19, exhibits genetic polymorphism, the activation of clopidogrel and consequently its antiplatelet action shows high interindividual variability. Some patients are nonresponsive. Omeprazole, an inhibitor of CYP2C19, reduces metabolic activation of clopidogrel and its antiplatelet action. However, like ticlopidine, the action of clopidogrel lasts 5–7 days due to irreversible blockade of platelet P2Y12 receptors. 

Reference: KD Tripathi's Essentials of Medical Pharmacology

Tooth affected with dentinogenesis imperfecta are generally of which shape

 # Tooth affected with dentinogenesis imperfecta are generally of which shape?

A. Tulip

B. Conical

C. Shell

D. Ovoid

The correct answer is A. Tulip.

Aberration in chromosome 4 (loci4q21.3) is associated with Dentinogenesis imperfecta. It encodes dentin specific sialophospho protein (DSPP) gene. Deficiency of sialoprotein is also suggested as a causative factor for Dentinogenesis imperfecta. Tooth affected with dentinogenesis imperfecta are generally tulip shaped. 

Brittle bone syndrome is caused by:

 # Brittle bone syndrome is caused by:

A. Improper synthesis of procollagen 

B. Polymerisation of collagen 

C. Increase osteoclastic activity 

D Increase fibroblastic activity 

The correct answer is A. Improper synthesis of procollagen.

Osteogenesis imperfecta, also known as Brittle Bone Disease, or 'Lobstein syndrome' is disorder of congenital bone fragility caused by mutations in the genes that codify for type I procollagen. This deficiency arises from an amino acid substitution of glycine to bulkier amino acids in the collagen triple helix structure. If the body does not destroy the improper collagen, the relationship between the collagen fibrils and hydroxyapatite crystals to form bone is altered causing brittleness. The following 4 types of osteogenesis imperfecta have been reported. Type I -mild form, type II -extremely severe, type III -severe, type IV -undefined. These partly depend on the genetic subtype. Type I and IV are the most common forms of osteogenesis imperfecta.