# Orthodontic tooth movement is affected by: A. Aspirin B. Tetracycline C. Metronidazole D. Fluoride The correct answer is A. Aspirin. • Prostaglandin E plays an essential role in the cascade of signals that leads to tooth movement, so the inhibitors of its activity affect tooth movement. Drugs that affect prostaglandin activity fall into two categories: - corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs) that interfere with prostaglandin synthesis and - other agents that have mixed agonistic and antagonistic effects on various prostaglandins. • In the body, prostaglandins are formed from arachidonic acid, which in turn is derived from phospholipids. Corticosteroids reduce prostaglandin synthesis by inhibiting the formation of arachidonic acid; NSAIDs inhibit the conversion of arachidonic acid to prostaglandins. • Most NSAIDs (aspirin, ibuprofen, Naprosyn, and many others) are prostaglandin inhibitors. The major exception is acetaminophen (Tylenol), whi...